Since many patients with CKD have evidence of chronic inflammation, as reflected by elevated C-reactive protein (CRP) levels, anemia of chronic disease, and elevated D-dimer and vonWillebrand factor levels [28-30], it is possible that hypoalbuminemia may reflect an inflammatory state, which may increase kidney disease progression [30], possibly by causing oxidative stress [31]. The gene discussed is VWF; the disease is Hypoalbuminemia.