In BALF the percentage of IFN-γ producing CD4+ Tcells was significantly higher in patients with sarcoidosis than in normal control subjects (mean ± SD, 53.1 ± 17.9 versus 38.1 ± + 7.7, p = 0.019) after the stimulation with PMA/ionomycin. This evidence concerns the gene CD4 and sarcoidosis.