PTH and hyperparathyroidism: Hyperparathyroidism has been proposed by some as a cause of uremic pruritus.[8] Cases of disappearance of pruritus after parathyroidectomy support this theory.[1,4,8] This hormone can indirectly lead to metabolic alterations that subsequently cause pruritus.[1] On the other hand, a direct role for parathyroid hormone in causing uremic pruritus has been questioned because of the failure of intradermal injections of PTH analogs to cause pruritus, and because of negative immunohistochemical studies for PTH in skin biopsy specimens.[19]