TLR4 and cystic fibrosis: In addition, the potential role of other single nucleotide polymorphisms in genes involved in innate immunity such as Toll-like receptor 4 Asp299Gly [6], Toll-like receptor 2 Arg753Gln [6] and mannose binding lectin [7], may influence the acquisition of P.aeruginosa in children with CF and more detailed investigation of these pathways in CF is indicated.