The EWS gene, at Chromosome 22 band q12, was first identified in Ewing's sarcoma by its association with FLI1 and ATF1 [16,17] and subsequently found in subsets of Ewing's sarcoma with either ERG or ETV1, and E1AF and FEV [17–21]. This evidence concerns the gene FLI1 and Ewing sarcoma.