As Atiprimod blocked STAT3 activation, inhibited MM cell proliferation, induced cell cycle arrest in U266-B1 cells at the G0/G1 phase, and reduced the levels of Bcl-2, Bcl-XL, and Mcl-1, we hypothesised that Atiprimod induces apoptotic cell death. This evidence concerns the gene BCL2L1 and Miyoshi myopathy.