TP53 is the most commonly aberrant gene in AII and AA – approximately 50% of these tumours have no wild-type TP53 and a further 10–15% have one mutated and one wild-type allele (Rasheed et al, 1994; Ichimura et al, 2000; Kato et al, 2000). This evidence concerns the gene TP53 and neoplasm.