Future research should no longer focus on risk of breast cancer in ITGB3 Leu33Pro homozygotes, but should rather try to examine other cancer subgroups like ovarian cancer, melanoma or yet other cancer subgroups (Bojesen et al, 2003), as explanations for the increased overall cancer risk in Leu33Pro homozygotes. This evidence concerns the gene ITGB3 and breast cancer.