CDH1 and squamous cell intraepithelial neoplasia: Previous studies have shown that the expression of E-Cadherin and β-Catenin, as evaluated immunohistochemically, is inversely proportional to the histologic grade in squamous intraepithelial lesions (SIL) of the cervix: expression of both markers is generally maintained in low-grade lesions and is lost in high grade lesions [34-36].