Our objectives are 1) to determine the frequency of loss of expression of E-Cadherin and β-Catenin in early stage cervical carcinomas 2) to determine whether the expression of either of these biomarkers is of prognostic significance 3) to specifically investigate whether there are any differences between the three major histological subtypes of cervical carcinoma with respect to expression of E-Cadherin and β-Catenin. The gene discussed is CDH1; the disease is cervical carcinoma.