The effects of factor VIIa on caspase 3 activity are sensitive to inhibitors of the phosphatidylinositol 3'-kinase and P42/P44 MAPK pathways; thus, factor VIIa appears to be a survival factor for TF-expressing cells and seems to mediate the survival of tumor cells during metastasis [14,92]. The gene discussed is TF; the disease is neoplasm.