In particular, well-differentiated oral carcinomas showed P-cad expression similar to normal oral mucosa or up-regulated, while P-cad expression homogeneously reduced in low-differentiated oral squamous cell carcinomas or its localization shifted to the cytoplasm, in accordance with other studies on oral mucosa [39] or gastrointestinal mucosa [48,63]. Here, CDH3 is linked to oral cavity squamous cell carcinoma.