ENO2 and goblet cell carcinoma: Because GCC is considered to be derived from crypt cells, there are other immunohistochemical techniques for their diagnosis including Cytokeratin 20 (CK20), CK7 (with the positivity of CK20 more than CK7), neuron-specific enolase (NSE), chromogranin A, serotonin, lysozyme, PGP 9.5, IgA and vimentin [7,14,24,27,33,34].