To adjust for prognostic factors, the clinical parameters described in Table 2 were included in the multivariate analysis using the Cox proportional hazards model, i.e., EGFR extent (<25% vs ≥25%), resection (complete [R0] vs R1), tumor stage (II vs III), preoperative total dose RT (44 vs 60 Gy), gender, tumor location (lower third vs other thirds), type of surgery, resection margins, age (≤64 vs >64 years old), preoperative concomitant chemo-radiotherapy (no vs yes), EGFR intensity (negative to moderate vs strong), delay from the last day of RT to the day of surgery (≤41 vs >41 days) and uT. Here, EGFR is linked to neoplasm.