NTN1 and endometrial cancer: More recently, an interesting study suggested that the DCC/netrin-1 pair is important in endometrial carcinogenesis because (i) DCC is lost in nearly all the endometrial cancer cell lines tested and (ii) re-expression of DCC in these cell lines drives apoptosis, a phenomenon blocked by the presence of netrin-1 (Kato et al, 2004).