VEGFA and neoplasm: Vascular endothelial growth factor overexpression has been shown in a number of tumour systems (Fujimoto et al, 1998; Lee et al, 2000), where it is believed to function as a paracrine angiogenic factor affecting endothelial cell signalling; however, the presence of VEGF receptors on tumour cells raises the possibility of VEGF family members also acting in an autocrine fashion on the tumour itself.