Overexpression of the EGF receptor (EGFR) in RCC has been recognised for some time and EGFR signalling is mitogenic for malignant and normal renal tubular cells (Gomella et al, 1989; Humes et al, 1991; Uhlman et al, 1995; de Paulsen et al, 2001). The gene discussed is EGFR; the disease is renal cell carcinoma.