A broad study of phosphorylated S6K1 in eight common tumour types found nearly all with some reactivity while intense staining (3+) was present in up to 60% of colon adenocarcinomas and nearly 50% of lymphomas, ovarian, melanoma, lung and brain tumours (Xu et al, 2004). The gene discussed is RPS6KB1; the disease is colon adenocarcinoma.