IGF1R and cancer: In this review we will summarise relevant studies on the role of IGF-1R in cancer with focus on: (1) the unique role of IGF-1R signalling in malignant cells; (2) the interactions between IGF-1R and tumour suppressor genes and proto-oncogenes; as well as (3) current attempts in targeting the IGF-1R as a potential option in cancer therapy.