IGF1R and cancer: Another aspect on a unique role of IGF-1R in cancer is based on several recent findings that loss of suppressor oncogenes as well as activation of proto-oncogenes is related to IGF-1R function and activity (Baserga, 1994; Girnita et al, 2000; Werner and Le Roith, 2000; Werner et al, 2000; Girnita et al, 2003; Zhao et al, 2004).