Sachdev et al (2003) used a single-chain antibody directed against IGF-1R (IGF-1R scFv-Fc) to examine the effects on IGF-1R signalling. In vivo treatment of mice bearing MCF-7 xenograft tumours with scFv-Fc resulted in near complete downregulation of IGF-1R. The gene discussed is IGF1R; the disease is neoplasm.