Pathologic fusion of the Ewing gene EWS to WT1 (t(11;22)(p13;q12)(EWS/WT1)) has been shown to abrogate the tumour suppressor function of WT1 and to generate an oncogenic chimeric protein capable of binding and activating the IGF-1R promoter (Karnieli et al, 1996). The gene discussed is WT1; the disease is neoplasm.