A sedentary lifestyle has also been associated with insulin resistance among non-diabetic individuals, independent of obesity.19,20 The regular practice of exercise increases the number of capillaries and muscle fibers, thereby favoring the availability of glucose mediated by insulin from these cells.21,22 It has already been demonstrated that even the practice of bouts of exercise stimulates the translocation of GLUT-4 to the plasmatic membrane and increases the transportation of glucose to skeletal muscles.20 Here, SLC2A4 is linked to obesity due to melanocortin 4 receptor deficiency.