APC and gastric cancer: We and others have previously demonstrated the frequent hypermethylation of CpG islands within the promoter regions of genes like hMLH1, E-cadherin, p15, p16, and APC in gastric cancer (Tsuchiya et al, 2000; Leung et al, 2001; To et al, 2002; Kang et al, 2003; Sarbia et al, 2004).