Altogether, 16 different B-raf exon 15 mutations (T1749C, g1757A, C1758A, T1760C, T1779C, T1787A, A1794T, g1795A, T1796A, T1803g, A1810g, A1823g, g1824A, A1830C, T1837C, T1847C) were detected in the 60 investigated cutaneous melanoma resection specimens. The gene discussed is BRAF; the disease is cutaneous melanoma.