In comparison to the 16 different protein mutations very recently described in 19/50 B-raf mutations bearing primary melanomas [6], a narrowing of the spectrum of predicted B-raf protein mutations is observed during transition from primary melanomas towards cutaneous/subcutaneous metastases (p = 0.04 upon Fisher's exact test; estimated odds ratio 2.64, 95% confidence interval 0.97–7.63). The gene discussed is BRAF; the disease is melanoma.