The occurence of valine substitution at B-raf amino acid position 599 (V599) or the detection of the V599E mutation were not associated with a change in the distribution of tumour thickness according to Breslow of the prededing primary melanomas (exact Wilcoxon rank sum test: p = 0.40 and p = 0.46, respectively). The gene discussed is BRAF; the disease is neoplasm.