RAF1 and melanoma: Altogether, the serine/threonine kinase B-raf, involved in the Ras-Raf-MEK-ERK-MAP kinase pathway of signal transduction, harbours mutations of it's kinase domain in 40% of 60 melanoma metastatic resection specimens which is not exceeding the mutation frequency in primary melanomas [6] and which is not associated with enhanced risk for subsequent further metastasis.