TF and diabetes mellitus: The diagnostic strategy is as follows: 1) To suspect the diagnosis from non-specific symptoms (such as persistent fatigue, arthralgias), and not only when presented with classical signs of HH (such as skin pigmentation, diabetes and cirrhosis); 2) Once the disease is suspected, the second step is to determine the serum transferrin saturation; 3) If the value of this iron parameter is elevated, molecular analysis of the main HFE mutations (C282Y +/- H63D) must be done to confirm the diagnosis of HH [20].