In the present study, no bona fide pathogenic germline alterations were identified in the CDKN2A/ARF and CDK4 loci among 42 Jewish, primarily Ashkenazi Israeli families, with a seemingly inherited predisposition to cutaneous melanoma, and in some, clustering of melanoma with NST, for deletions and point mutations in the CDKN2A/ARF and CDK4 loci. Here, CDK4 is linked to melanoma.