The familial clustering of melanoma and NST has been recognised and designated as the Melanoma and Neural System Tumour syndrome (MM-NST) (OMIM # 155755), and in a small subset of melanoma-NST kindreds germline mutations, mainly deletions affecting the CDKN2A/ARF gene and cosegregating with both tumours, were described. This evidence concerns the gene CDKN2A and neoplasm.