These data identify MMP2, MMP10, MMP15, MMP26, MMP23, TIMP3, TIMP4, hepsin, MTSP1, PAI1, uPAR and maspin as genes that require further study at the protein level and via immunohistochemical analysis to elucidate their contributions to prostate cancer progression. Here, SERPINB5 is linked to Familial prostate cancer.