Interestingly, Graells et al (2004) demonstrated that the proangiogenic vascular endothelial growth factor (VEGF), which is frequently highly expressed in uveal melanoma (Stitt et al, 1998; Sheidow et al, 2000), could operate in cutaneous melanoma as a survival factor through increasing MAPK and PI3K pathway activity. This evidence concerns the gene VEGFA and cutaneous melanoma.