In addition, there is emerging evidence from animal models that VEGF-C overexpression may promote metastatic spread to lymph nodes (Schietroma et al, 2003) and clinically, high expression of VEGF-C and/or -D has been found to predict for nodal metastasis and poor prognosis in a number of different tumour types (Kurahara et al, 2004; Zeng et al, 2004; Suzuki et al, 2005). The gene discussed is VEGFC; the disease is neoplasm.