An additional consideration is the knowledge that VEGF is a key driver of angiogenesis early in tumour development, but a range of other proangiogenic factors, such as bFGF and PDGF, are likely to contribute to vascular development at later stages (Relf et al, 1997; Pavlakovic et al, 2001; Kerbel, 2004). The gene discussed is VEGFA; the disease is neoplasm.