This protein family belongs to the death domain super-family consisting of the Death Domain (DD), Death Effecter Domain (DED) and the Pyrin, AIM (Absent-in-melanoma), ASC, Apoptosis-associated speck-like protein containing a caspase recruitment domain CARD, and Death-Domain (DD)-like (PAAD/DAPIN/PYRIN) domain subfamilies. This evidence concerns the gene MEFV and melanoma.