However, an opposing scenario of response to S100A4 was recently reported by Pedersen et al (2004), who found that the S100A4-secreting human osteosarcoma cell line OHS are more sensitive to IFN-γ-mediated apoptosis than anti-S100A4 ribozyme transfected counterpart II-11b cells, which do not secrete S100A4 into conditioned medium. This evidence concerns the gene S100A4 and osteosarcoma.