In the present study, we therefore aimed to investigate the relation between the concentrations of three cytokines (TNFα, IL-6, and MCP-1) and several neuropeptides (BN/GRP, SP, NPY, VIP, and CGRP) in the synovial fluid from patients with RA, stratified for early and long-standing disease. This evidence concerns the gene IL6 and rheumatoid arthritis.