The expression of Ksp-cadherin mRNA and the absence of the intact protein were also observed in RCC tissue, whereas in normal kidney tissue the mRNA was present and a strong specific signal at 130 kDa could be detected by immunoblotting, indicating that the used anti-human Ksp-cadherin antibody is successfully applicable for this method (Figures 3 and 4). This evidence concerns the gene CDH16 and renal cell carcinoma.