Some RCC cell lines also express E-cadherin and cadherin-8 (Shimazui et al, 1996; Blaschke et al, 2002), but since these cadherins are only found to be expressed on distal tubules or during development, respectively, their expression in the renal tumour cells must be regarded as an aberrant expression pattern. This evidence concerns the gene CDH1 and renal cell carcinoma.