The median NT-proBNP value of patients with a positive cardiovascular history (hypertension, heart failure, arrhythmias) was 67,00 on day 0 (mean = 90,57+/-66,48, range: 9–165), 39,00 on day 7 (mean = 56,29+/-56,91, range: 9–176) and 27,00 on day 21 (mean = 37,71+/-36,13, range: 5–101). The gene discussed is NPPB; the disease is heart failure.