In one study of ovarian carcinoma, SOCS 1 and 2 genes were demonstrated to be silenced due to hypermethylation (Sutherland et al, 2004) and a number of studies have identified increased levels of STAT proteins (particularly STAT 3) in ovarian cancers (Huang et al, 2000; Chen et al, 2004; Meinhold-Heerlein et al, 2005; Silver et al, 2004). The gene discussed is SOAT1; the disease is ovarian cancer.