The incidences of fatigue, fever without neutropenia, HFS, rash/desquamation, pruritus, diarrhoea, stomatitis/pharyngitis, sensory neuropathy, and elevated AST, ALT, and ALP were increased in the groups receiving >300 mg b.i.d. BAY 43-9006. This evidence concerns the gene GPT and sensory peripheral neuropathy.