There is evidence that EGFR expression is involved in prostate cancer development and in progression to androgen independence (Di Lorenzo et al, 2002), and an in vitro study has provided evidence that androgens increase the EGFR levels in androgen-sensitive prostate cancer cells and that EGFR signaling is essential for androgen-induced proliferation and survival (Torring et al, 2003). This evidence concerns the gene EGFR and Familial prostate cancer.