BCR-ABL-positive human leukaemia cell lines such as K562, KU812, MC-3, NMBA-1, KBM-5, Z-33, Z-119, Z-181, human glioma cells (U-87, U-343) and human GIST (GIST882) are more sensitive to IM (Capdeville et al, 2002). The gene discussed is ABL1; the disease is central nervous system cancer.