Barron-Casella et al (1995) isolated cDNAs homologues for the beta subunit of chicken Cap Z from human retinal cDNA libraries. This gene encodes the beta subunit of the barbed-end actin binding protein that regulates growth of the actin filament by capping the barbed end of growing actin filaments. Those investigators mapped the CAPZB gene to 1p36.1, which has frequent loss of heterozygosity observed in neuroblastomas (Fong et al, 1989) and in oropharyngeal epithelial carcinomas (Grati et al, 2000). This evidence concerns the gene CAPZB and neuroblastoma.