The mechanisms involved in suppression of tumor growth by an omega-3 fatty acid enriched diet include: 1) decreased expression of cyclooxygenase-2, reducing angiogenesis and decreasing cancer cell proliferation, 2) suppression of nuclear factor κB activation and bcl-2 expression, allowing apoptosis of cancer cells, 3) suppression of the oncogenes AP-1 and ras, 4) induced differentiation of the cancer cells, 5) reduction in aromatase activity that decreases estrogen levels, 6) inhibition of later steps in the tumor angiogenesis process. The gene discussed is CYP19A1; the disease is neoplasm.