PTGS2 and cancer: The mechanisms involved in suppression of tumor growth by an omega-3 fatty acid enriched diet include: 1) decreased expression of cyclooxygenase-2, reducing angiogenesis and decreasing cancer cell proliferation, 2) suppression of nuclear factor κB activation and bcl-2 expression, allowing apoptosis of cancer cells, 3) suppression of the oncogenes AP-1 and ras, 4) induced differentiation of the cancer cells, 5) reduction in aromatase activity that decreases estrogen levels, 6) inhibition of later steps in the tumor angiogenesis process.