From 42 UICC IV cases that could be scored for lymphocyte infiltration at primary tumour site, only seven (16.7%) primary tumours had a marked peritumoural lymphocyte infiltration with CLR, whereas in the collective with UICC grade I–III the relation of CLR-positive tumours was 35 out of 76 (46.1%, Fisher's exact test: P=0.001). The gene discussed is DCLK3; the disease is neoplasm.