In prostate cancer, the expression of the PIM1 protein has been shown to correlate with clinical outcome (Dhanasekaran et al, 2001), and the novel detection of this proto-oncogene in carcinoid tumour cells warrants further studies to explore its role as a potential prognostic marker also in NE GI tumours. Here, PIM1 is linked to digestive system neuroendocrine neoplasm.