While TRAIL alone induces apoptosis in sensitive cancer cell lines, TRAIL activity can be enhanced upon coexposure with various chemotherapeutic agents (Gliniak and Le, 1999; Keane et al, 1999; Yamanaka et al, 2000; Bouralexis et al, 2001; Evdokiou et al, 2002; Shimoyama et al, 2002). This evidence concerns the gene TNFSF10 and cancer.