HGS-ETR1 induction of cell killing and mechanism of action were analysed in multiple tumour cell lines (SW480, Colo205, HCT116, H2122, H460, SU.86.86, RL95-2, ST486, JURL-MK1, A498, SNU398, and WM793), representing various tumour types (Table 1). Here, HGS is linked to neoplasm.