The four tumours with mutations had significantly (P<0.001) higher levels of ICAM1 expression in tumoural tissue vs normal tissue (range of the ratio between the expressions of ICAM1 in tumoural tissues vs normal tissue: 3.2–5.0; mean±standard deviation=3.9±0.8) (Table 3) than the 22 cases without GRIM-19 mutation (range: 0.9–2.4; mean±standard deviation=1.4±0.4). The gene discussed is NDUFA13; the disease is neoplasm.