Since ret/PTC rearrangements and B-RAF mutations are particularly prevalent in papillary carcinomas regardless of whether or not they have Hürthle cell features (Grieco et al, 1990; Soares et al, 1998, 2003; Sugg et al, 1998; Cohen et al, 2003; Kimura et al, 2003), we have also searched for the aforementioned genetic alterations in Hürthle cell carcinomas with GRIM-19 mutations. The gene discussed is RET; the disease is thyroid gland papillary carcinoma.