Also, the similarity in expression of ETAR, VEGF-C, Flt-4, and Her-2/neu between the in situ and the concomitant invasive carcinomas and the observed close concordance with respect to nuclear grading between both components is in agreement with previous reports on different lines of genetic evolution of invasive breast cancer (Buerger et al, 1999, 2001; Mommers et al, 2001). This evidence concerns the gene FLT4 and invasive breast carcinoma.