Coexpression of ligand and receptor in the tumour epithelium was most frequently found for the VEGF-C/Flt-4 combination (87% of cases), followed by the combinations of VEGF-C/KDR (51%), ET-1/ETAR (37%), ET-1/ETBR (26%), and VEGF-A/KDR (25%). This evidence concerns the gene EDN1 and neoplasm.