We got the following ranking of the predictive power to explain the occurrence of new VTE cases during a theoretical 10-year period (defined by our model) in declining order: Medical history of VTE, family history of VTE (1st degree relatives), age at baseline 1993, body mass index (BMI), factor V Leiden (FVL) or prothrombin mutation (PTM), family history of varicose veins, protein C, AT level, hormone ever use, MTHFR carrier status, and OC ever use. This evidence concerns the gene MTHFR and Varicose veins.