TP53 and gastric cancer: Panani et al (1995) have shown gains of chromosome 8 in gastric adenomas. One study reports frequencies of c-myc overexpression in 36% of gastric cancers, and 15% of chronic gastritis. All these abnormalities were also associated with abnormal p53 expression (Nardone et al, 1999). The significant link between H. pylori-negative patient tissue and chromosome 8 loss has an unknown basis that might be worth pursuing.