In contrast to the SIN model described above, CCI involves both inflammation of, and trauma to, this nerve, To test whether AAV2-r-IL-10 could reverse established thermal hyperalgesia or low threshold mechanical allodynia induced by CCI, the plantar surface of the rat hindpaws were first assessed for their responses to low threshold mechanical stimuli (von Frey test) and radiant heat stimuli (Hargreaves test) prior to (BL) and again on Days 3 and 10 after surgery. The gene discussed is IL10; the disease is squamous cell intraepithelial neoplasia.