Lack of TNFα has been reported to result in a significant delay of remyelination in a cuprizone-induced demyelination model, due to a reduced number of proliferating OL progenitors [45], since the signal transduction of TNFα via p75 TNF receptor 2 (TNFR2) is known to induce proliferation of OL progenitors [27,28]. Here, TNF is linked to Peripheral demyelination.