Multiepitope vesicles can also be conveniently made (Boeckler et al, 1999), that can carry different Tc peptide epitopes, or combinations of Tc epitopes with T-helper (Th) epitopes; this latter strategy is particularly appealing, because CD4+ T-cell responses are believed to play a key role in tumour immunity such as, for example, in vivo CD8+ T-cell response priming (Wang and Livingstone, 2003) and/or memory generation (Bourgeois and Tanchot, 2003). Here, CD4 is linked to neoplasm.