The current study updates the follow-up period through 2002 and examines the relation between the all five major classes of AHTs (Capella, 1993), that is, diuretics, beta blockers, calcium antagonists, angiotensin converting enzymes (ACE) inhibitors and angiotensin II antagonists, as well as specific classes of diuretics, in relation to RCC. The gene discussed is ACE; the disease is renal cell carcinoma.