Use of ACE inhibitors (relative rate (RR)=1.9, 95% CI=1.4–2.5), beta blockers (RR=1.7, 95% CI=1.3–2.2), calcium antagonist (RR=1.4, 95% CI=1.0–1.8) and diuretics (RR=1.6, 95% CI=1.2–2.0) were all significantly associated with RCC. The gene discussed is ACE; the disease is renal cell carcinoma.