It has been shown that the levels of DNA adducts are positively related to risk of IUGR (Dejmek at al 2000; Šrám et al. 1999), birth weight, birth length, and head circumference (Perera et al. 1998, 1999), and hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus mutation frequency in infants (Perera et al. 2002). This evidence concerns the gene HPRT1 and fetal growth restriction.