CXCR6/Bonzo/STRL33 is a chemokine receptor that can serve in conjunction with CD4 as a co-receptor for infection with some human and most simian immunodeficiency viruses (HIV-1, HIV-2, and SIV) [16] and, similarly to CCR5 and CXCR3, has an expression pattern restricted to memory/effector T cells such as NKT cells [17,18,19,20,21]. This evidence concerns the gene CXCR6 and infection.